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heart

TRANSTHYRETIN AMYLOID
CARDIOMYOPATHY (ATTR-CM):

A DISEASE THAT
CAN GO UNDETECTED
一種常被忽略的心臟疾病

ATTR-CM is a life-threatening, progressive, infiltrative, rare disease that can often be overlooked as a cause of heart failure. Transthyretin (TTR) proteins with unstable structures misfold and aggregate into amyloid fibrils, which deposit in the heart and other organs.1-3 It is critical to recognize the diagnostic clues so you can identify this disease.

References: 1. Witteles RM, Bokhari S, Damy T, et al. Screening for transthyretin amyloid cardiomyopathy in everyday practice. JACC Heart Fail. 2019;7(8):709-716. 2. Maurer MS, Hanna M, Grogan M, et al. Genotype and phenotype of transthyretin cardiac amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). J Am Coll Cardiol. 2016;68(2):161-172. 3. Benson MD, Buxbaum JN, Eisenberg DS, et al. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2018;25(4):215-219.